Davide Calabria is also reportedly out of the Milan squad to face Juventus, joining Zlatan Ibrahimovic and Olivier Giroud, after a muscular problem.
It kicks off on Sunday at the Allianz Juventus Stadium at 19.45 UK time (18.45 GMT).
The Rossoneri have an injury crisis after their 3-2 Champions League defeat to Liverpool at Anfield.
Calabria picked up a muscular issue and Sky Sport Italia report that tests showed an elongation of the flexor muscles in the right thigh.
It is not a serious problem, so there are no lesions, but he will be replaced by Alessandro Florenzi at right-back in Turin.
Coach Stefano Pioli confirmed both Ibrahimovic and Giroud will not be in the squad, as the Swede still has an inflamed Achilles tendon and the Frenchman aggravated his lumbago.
Rade Krunic is also in doubt, while Tiemoue Bakayoko, Andrea Conti and Junior Messias are unavailable.
This means Ante Rebic should again be the centre-forward, although Pioli did note that ex-Genoa and Monaco striker Pietro Pellegri could make his debut tomorrow.
Il #Milan perde anche Calabria per la #Juve : guaio muscolare, le sue condizioni #JuveMilan https://t.co/YI7s9BDE6L pic.twitter.com/P1j8UrcO2h
— calciomercato.com (@cmdotcom) September 18, 2021