Nicolò Barella and Edin Dzeko were replaced in the second half of the derby della Madonnina with suspected flexor injuries.
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The Italy international was replaced by Arturo Vidal after 68 minutes. According to DAZN, he suffered a flexor injury at his right thigh.
Barella has been included in the Italy squad for the crucial World Cup qualifying matches against Switzerland and Northern Ireland, scheduled for next week.
The Azzurri will host Switzerland at the Stadio Olimpico in Rome on Friday and visit Northern Ireland on Monday, 15.
That would be one more issue for Roberto Mancini who must already cope without Marco Verratti as the PSG star is on the treatment table with a hip injury.
There was even more concern for Inter less than ten minutes later, when Edin Dzeko was replaced, still with flexor problems, with Joaquin Correa taking his place.
According to DAZN, Alessandro Bastoni also had physical issues when he was replaced by Federico Dimarco in the final minutes of the game.