The Wales international lunged in on Immobile moments after kick-off at the Stadio Olimpico.
Immobile did not take the gift, as he blasted the penalty into the Roman sky.
At least there is no more ‘double jeopardy’ in these situations now, so while De Sciglio was sent off, Ampadu only got a yellow card.
The 22-year-old is in his second Serie A stint after a spell at Venezia last season and remains on loan from Chelsea.
Ampadu has struggled a little in the Italian League, as this was his 31st Serie A appearance, amassing 13 yellow cards and two red.