Atalanta know a victory will qualify them for the Champions League for the first time in their history, but a quirk of fate means Sassuolo are both home and away.
Federico Santander bagged a brace to give Bologna their seventh consecutive home win, despite a Napoli comeback in this 3-2 thriller.
Thanks to various head-to-head records, both Cagliari and Udinese can go into the final round assured of their Serie A status.
Fiorentina and Genoa are more accustomed to fighting for Europe than Serie A safety, but both could still be relegated this weekend.
Frosinone and Chievo concluded their seasons and Serie A experiences with a goalless draw, although the Flying Donkeys set an unfortunate record.
Luciano Spalletti’s Inter host Empoli with both sides taking their seasons right down to the wire in the battles for Champions League football and Serie A safety.
Roma have an extremely slim chance of qualifying for the Champions League, but this is above all a farewell to Daniele De Rossi.
Sampdoria host champions Juventus in Max Allegri’s swansong, but all eyes are on Capocannoniere Fabio Quagliarella.
Milan need to beat SPAL and hope that either Atalanta or Inter drop points in order to qualify for the Champions League.
Lazio have already secured their Europa League group status after winning the Coppa Italia, but Torino threw away their continental ambitions.