Paulo Dybala and Mario Mandzukic should be back in the starting XI for Juventus, while Roma rely on Stephan El Shaarawy and Edin Dzeko.
It kicks off at 19.45 GMT, follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
This is a Scudetto showdown, as Juve are currently in second place and the Giallorossi are fourth, but with a game in hand.
Paulo Dybala and Mario Mandzukic should be back in the starting XI for Juventus, while Roma rely on Stephan El Shaarawy and Edin Dzeko.
It kicks off at 19.45 GMT, follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
This is a Scudetto showdown, as Juve are currently in second place and the Giallorossi are fourth, but with a game in hand.
Max Allegri is keeping everyone guessing, as he is without Gigi Buffon, Mattia De Sciglio and Benedikt Howedes, so Wojciech Szczesny starts against his old club.
Dybala was dropped for two Serie A rounds in a row and broke his goal drought in the Coppa Italia win over Genoa midweek.
La Joya is expected to return and with him the 4-2-3-1 formation that had been abandoned in favour of 4-3-3.
Mandzukic and Juan Cuadrado have shaken off injuries, sending Douglas Costa and Federico Bernardeschi back to the bench.
Juventus could also push Andrea Barzagli to right-back, in effect a three-and-a-half-man defence, often used in the Champions League.
Roma are missing Gregoire Defrel and Rick Karsdorp, but otherwise have a full squad to choose from.
Eusebio Di Francesco rarely strays from his beloved 4-3-3 system but, unlike mentor Zdenek Zeman, he makes sure the defence is solid.
In fact, they have the best defensive record in Serie A this season, while Juve are the most prolific in attack.
Alessandro Florenzi should get the right-back spot with Daniele De Rossi available again after suspension.
El Shaarawy and Diego Perotti are expected to flank centre-forward Edin Dzeko, leaving Patrik Schick on the bench.
Juventus (probable): Szczesny; Barzagli, Benatia, Chiellini, Alex Sandro; Pjanic, Khedira; Cuadrado, Dybala, Mandzukic; Higuain
Roma (probable): Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Strootman; El Shaarawy, Dzeko, Perotti