Juventus have Gigi Buffon in goal, Douglas Costa as a trequartista and Matthijs de Ligt in defence, but Cristiano Ronaldo is out ill against Udinese in the Coppa Italia.
It kicks off at 19.45 GMT and the winners go on to face either Roma or Parma in the Quarter-Final on January 22.
Cristiano Ronaldo will not even be on the bench this evening, as a statement from Juve confirmed he had a bout of sinusitis today.
Juventus have Gigi Buffon in goal, Douglas Costa as a trequartista and Matthijs de Ligt in defence, but Cristiano Ronaldo is out ill against Udinese in the Coppa Italia.
It kicks off at 19.45 GMT and the winners go on to face either Roma or Parma in the Quarter-Final on January 22.
Cristiano Ronaldo will not even be on the bench this evening, as a statement from Juve confirmed he had a bout of sinusitis today.
Gianluigi Buffon takes the gloves from Wojciech Szczesny, with Daniele Rugani and Matthijs de Ligt given their first start together after Merih Demiral’s season-ending injury.
Rodrigo Bentancur is available, as his ban only applies to Serie A, so the Uruguay international is given the nod in midfield with Adrien Rabiot and Federico Bernardeschi.
Sami Khedira, Demiral and Giorgio Chiellini are still out injured, but Douglas Costa is given a new role as a trequartista behind Paulo Dybala and Gonzalo Higuain.
Udinese are finding their form under caretaker manager Luca Gotti, fresh from a 3-0 Serie A victory over Sassuolo.
The Friulani reached the Round of 16 by beating Sudtirol 3-1 and Bologna 4-0.
Ilija Nestorovski partners Lukasz Teodorczyk in a powerful front two, with Antonin Barak, Walace and Mato Jajalo pulling the midfield strings.
Juventus: Buffon; Danilo, De Ligt, Rugani, Alex Sandro; Bentancur, Rabiot, Bernardeschi; Douglas Costa; Higuain, Dybala
Juventus bench: Szczesny, Pinsoglio, Pjanic, Ramsey, Matuidi, Cuadrado, Bonucci, Pjaca, Emre Can, Coccolo
Udinese: Nicolas; Opoku, De Maio, Nuytinck; Ter-Avest, Barak, Jajalo, Walace, Sema; Nestorovski, Teodorczyk
Udinese bench: Musso, Perisan, Troost-Ekong, Fofana, Okaka, De Paul, Lasagna, Stryger-Larsen, Mandragora, Becao
Ref: Aureliano