Krzysztof Piatek and Ante Rebic lead the Milan attack with a debut for Simon Kjaer in their Coppa Italia Round of 16 clash with SPAL, who start Bryan Dabo.
It kicks off at 17.00 GMT and the winners go on to face Torino in the Quarter-Finals.
Zlatan Ibrahimovic made a winning contribution with his goal in the 2-0 victory at Cagliari, but the veteran is rested in favour of Piatek and an extremely rare Rebic start.
Krzysztof Piatek and Ante Rebic lead the Milan attack with a debut for Simon Kjaer in their Coppa Italia Round of 16 clash with SPAL, who start Bryan Dabo.
It kicks off at 17.00 GMT and the winners go on to face Torino in the Quarter-Finals.
Zlatan Ibrahimovic made a winning contribution with his goal in the 2-0 victory at Cagliari, but the veteran is rested in favour of Piatek and an extremely rare Rebic start.
Suso and Lucas Paqueta are again dropped to the bench, confirming their status as being on the transfer market, but Kjaer makes his debut after a loan move from Sevilla, via Atalanta.
Gianluigi Donnarumma is carrying a slight injury, so his older brother Antonio steps in.
SPAL rely on Sergio Floccari and former Milan youth product Alberto Paloschi, supported by Gabriel Strefezza and debutant Bryan Dabo, who only completed his transfer from Fiorentina on Monday.
Milan: A Donnarumma; Conti, Kjaer, Romagnoli, Theo Hernandez; Castillejo, Krunic, Bennacer, Bonaventura; Piatek, Rebic
SPAL: Berisha; Tomovic, Vicari, Igor; Murgia, Jankovic, Dabo, Strefezza, Tunjov; Paloschi, Floccari