Bjorn Kuipers of the Netherlands is the referee for Inter-Barcelona, while Cuneyt Cakir will officiate Napoli’s Champions League decider with Genk.
The final Champions League group games are next week and it is still possible for all four Italian sides to reach the Round of 16.
Inter know a victory over already-qualified Barcelona would be enough at San Siro.
Dutch referee Kuipers has been assigned to this crunch match, with Pol van Boekel in the VAR booth.
They are assisted by Sander van Roekel and Erwin Zeinstra on the touchline.
Napoli need only a point against Belgians Genk to be sure of their spot in the knockout rounds.
Their match at the Stadio San Paolo has been assigned to Turkish referee Cuneyt Cakir, with fellow countryman Mete Kalkavan in the VAR booth.
Bahattin Duran and Tarik Ongun wield the offside flags.
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