Inter start Ivan Perisic, Mauro Icardi and Lautaro Martinez together as they host minnows Benevento in the Coppa Italia Round of 16.
It kicks off at 17.00 GMT at San Siro and the winners go on to face Lazio in the quarter-final later this month.
The game will be played behind closed doors as punishment for Inter ultras repeatedly aiming racist chants at opposition players.
Inter start Ivan Perisic, Mauro Icardi and Lautaro Martinez together as they host minnows Benevento in the Coppa Italia Round of 16.
It kicks off at 17.00 GMT at San Siro and the winners go on to face Lazio in the quarter-final later this month.
The game will be played behind closed doors as punishment for Inter ultras repeatedly aiming racist chants at opposition players.
Defender Andrea Ranocchia and goalkeeper Daniele Padelli finally get their first appearances of the season for Inter, with Henrique Dalbert and Roberto Gagliardini also getting rare starts.
There isn’t too much squad rotation, as Icardi is supported by Lautaro Martinez in a 4-4-2 formation, with Perisic, Marcelo Brozovic and Antonio Candreva in midfield.
This is an historic occasion for Benevento, as after last term’s debut Serie A season, it is the first time they have ever reached the last 16 of the Coppa Italia.
Goalkeeper Christian Puggioni has been left behind amid rumours of a January exit, with Nicolas Viola, Raul Asencio and Giovanni Volpicelli unavailable.
They start Roberto Insigne, who is on loan from Napoli and the younger brother of Lorenzo, with impressive veteran Massimo Coda in attack.
Inter: Padelli; Vrsaljko, Skriniar, Ranocchia, Dalbert; Candreva, Gagliardini, Brozovic, Perisic; Lautaro Martinez, Icardi
Inter bench: Handanovic, Berni, De Vrij, Vecino, Keita, Nainggolan, Joao Mario, Politano, Asamoah, Borja Valero, Miranda, D’Ambrosio
Benevento: Montipò; Di Chiara, Antei, Tuia; Improta, Bandinelli, Buonaiuto, Tello, Letizia; Insigne, Coda
Benevento bench: Gori, Sparandeo, Del Pinto, Billong, Maggio, Costa, Gyamfi, Cuccurullo, Ricci, Sanogo, Zagari, Armenteros
Ref: Giua