Roma give Cengiz Under and Maxime Gonalons rare starts, partnering Edin Dzeko and Stephan El Shaarawy against SPAL.
It kicks off at 17.30 GMT, follow the build-up and action from this game and Napoli–Juventus on the LIVEBLOG.
Eusebio Di Francesco has to revitalise his squad after their surprise 1-1 draw with Genoa in Serie A and 2-0 Champions League defeat to Atletico Madrid.
Roma give Cengiz Under and Maxime Gonalons rare starts, partnering Edin Dzeko and Stephan El Shaarawy against SPAL.
It kicks off at 17.30 GMT, follow the build-up and action from this game and Napoli-Juventus on the LIVEBLOG.
Eusebio Di Francesco has to revitalise his squad after their surprise 1-1 draw with Genoa in Serie A and 2-0 Champions League defeat to Atletico Madrid.
Daniele De Rossi was sent off for slapping Gianluca Lapadula in the Genoa game and therefore begins a two-match ban.
There’s a lengthy injury list too, missing Radja Nainggolan, Diego Perotti, Gregoire Defrel and Rick Karsdorp.
Former Sampdoria striker Patrik Schick was expected to get his first start after a series of fitness problems, starting with an irregular heartbeat that ultimately scuppered his summer transfer to Juventus.
Instead, Turkish talent Cengiz Under completes the trident with Dzeko and El Shaarawy, while Lorenzo Pellegrini and Gonalons fill out the midfield.
SPAL have had a rough week, as they fumbled a half-time lead to lose 2-1 at Chievo, then crashed out of the Coppa Italia with a shock home defeat to Cittadella.
Coach Leonardo Semplici is forced to do without Sauli Vaisanen, Bartosz Salamon, Mirco Antenucci, Filippo Costa and Alex Meret.
Alberto Paloschi leads the attack with ex-Inter youth product Federico Bonazzoli, leaving former Roma striker Marco Borriello on the bench.
The last SPAL success was on October 29 against Genoa, followed by two draws with Atalanta and Fiorentina, then the 2-1 loss to Chievo.
This fixture hasn’t been played in Serie A since 1967-68, although there was a Coppa Italia meeting in August 1982.
Roma: Alisson; Florenzi, Juan Jesus, Manolas, Kolarov; Strootman, Gonalons, Pellegrini; Under, Dzeko, El Shaarawy
SPAL: Gomis; Cremonesi, Vicari, Felipe; Lazzari, Grassi, Viviani, Rizzo, Mattiello; Paloschi, Bonazzoli
Ref: Abisso