Francesco Totti is back in the Roma line-up after a month out, but they welcome Antonio Di Natale’s Udinese.
It kicks off at 20.00 GMT, click here for a match preview .
The Giallorossi have effectively given up hope of taking the Scudetto off Juventus after falling 14 points behind the leaders, even with a game in hand.
Failure to win this evening will see that gap open up even more, while Napoli are closing in behind them in the race for that second automatic Champions League spot after last week’s San Paolo result.
The good news is that Totti is back in the side for the first time since suffering a thigh strain on February 14.
This line-up could work as a 4-3-3 with Gervinho and Mattia Destro, or as a 4-2-3-1 with Rodrigo Taddei joining the group fanning out behind the centre-forward.
Miralem Pjanic and Radja Nainggolan form the midfield after Kevin Strootman’s season was ended by a knee ligament injury.
Daniele De Rossi is still suspended with Federico Balzaretti sidelined.
Udinese are fresh from a 1-0 victory over Milan and have their own veteran superstar in attack, as Di Natale is in the top 10 all-time scorers in Serie A history.
He is supported by Roberto Pereyra, but Bruno Fernandes is suspended and Gabriel Silva injured, but Silvan Widmer has shaken off a knock to start in midfield.
Roma: De Sanctis; Torosidis, Benatia, Castan, Dodó; Nainggoan, Taddei, Pjanic; Gervinho, Destro, Totti
Udinese: Scuffet; Heurtaux, Danilo, Domizzi; Widmer, Pinzi, Allan, Badu, Basta; Pereyra, Di Natale
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!