Inter complete their Europa League group at home to Neftci, but use Esteban Cambiasso and Alvaro Pereira in defence.
The Nerazzurri have already qualified for the next round in second place behind Rubin Kazan, while Azerbaijani club Neftci are out of the competition.
This fixture kicks off at 20.05 GMT at San Siro and Coach Andrea Stramaccioni takes the opportunity to test out some younger faces.
Walter Samuel starts because he is suspended for Sunday’s Serie A clash with Napoli and he is joined at centre-back by Cambiasso, who has taken this role several times in Europe, plus Alvaro Pereira at left-back.
Philippe Coutinho supports Marko Livaja alongside a group of Primavera starlets, while Antonio Cassano is on the bench.
Inter: Belec; Jonathan, Cambiasso, Samuel, Alvaro Pereira; Romanò, Benassi; Pasa, Garritano, Coutinho; Livaja
Inter bench: Castellazzi, Bandini, Donkor, Nagatomo, Belloni, Terrani, Cassano
Neftci: Stamenkovic; Shukurov, T Guliyev, Mitreski, Bertucci; Sadygov, Ramos; Wobay, Flavinho, Imamverdiyev; Canales
Neftci bench: Balayev, Yunuszade, Abdullayev, Seyidov, Nasimov, Nurahmadov, Mehdiyev