A decimated Juventus look to Alessandro Del Piero against Salzburg, while Palermo bring back Fabrizio Miccoli away to CSKA Moscow.
The Europa League Matchday 4 kicks off with the 18.00 UK time matches.
Juve welcome Salzburg without 12 first team players, as Gigi Buffon, Armand Traore, Leandro Rinaudo, Davide Lanzafame, Zdenek Grygera, Vincenzo Iaquinta, Alex Manninger, Giorgio Chiellini, Felipe Melo and Jorge Martinez are injured.
With Fabio Quagliarella, Alberto Aquilani, Fabio Grosso and Hasan Salihamidzic unavailable for this competition, Coach Gigi Del Neri's hands are tied.
He has had to field Simone Pepe as a full-back and 19-year-old youth team player Manuel Giandonato in midfield, while Del Piero partners Amauri up front.
There were doubts over Momo Sissoko due to a muscular problem in training, but he is in the starting XI. Milos Krasic can play, as his two-match ban for diving only applies to Serie A.
Palermo welcome back Miccoli, who has barely featured since undergoing surgery at the end of last season.
His creativity is sorely needed, as Javier Pastore is suspended following his red card in the last round, when CSKA won 3-0 at the Stadio Barbera. Mattia Cassani was expected to start, but is on the bench in favour of Darmian.
The Rosanero are struggling in the Europa League with just three points from as many games. Sparta Prague are on four and CSKA Moscow clear in front with nine.
CSKA have not even got striker Doumbia on the bench, so Tomas Necid partners Vagner Love.
Juventus: Storari; Motta, Bonucci, Legrottaglie, Pepe; Krasic, Sissoko, Giandonato, Marchisio; Del Piero, Amauri
Juventus bench: Costantino, Liviero, Buchel, Boniperti, Giannetti, Libertazzi, Camilleri
Salzburg: Tremmel; Schwegler, Sekagya, Afolabi, Hinteregger; Schiemer, Zarate, Mendes da Silva, Pokrivac, Jantscher; Wallner
Salzburg bench: Walke, Dudic, Augustinussen, Hierländer, Boghossian, Leitgeb, Alan
CSKA Moscow: Akinfeev; Nababkin, V Berezutski, Semberas, Shennikov; Tosic, Mamaev, Honda, Mark Gonzalez; Vagner Love, Necid
CSKA bench: Chepchugov, Ignashevich, Dzagoev, Odiah, Aldonin, Rahimic, Oliseh
Palermo: Benussi; Glick, Bovo, Goian; Nocerino; Darmian, Rigoni, Kasami, Garcia; Maccarrone, Miccoli
Palermo bench: Sirigu, Munoz, Joao Pedro, Cassani, Balzaretti, Pinilla, Ardizzone
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!