It’s a battle of two early relegation favorites as Atalanta host Serie A newcomers Frosinone at the Stadio Atleti Azzurri d’Italia in Bergamo.
Sassuolo’s dream start to the season continues, as Antonio Floro Flores snatched a late victory away to rivals Bologna.
The stadio Alberto Braglia in Modena, Carpi’s adopted home for the season, will host the match between the Serie A newcomers in their first ever Serie A home game and the cautiously optimistic Inter.
After a dismal performance in Germany saw Lazio eliminated from the Champions League, the Aquile will be looking to bounce back against an in-form Chievo.
Genoa host Verona on Sunday with both teams looking for their first win of the new season.
Milan got their first win, as Carlos Bacca and Luiz Adriano broke Serie A ducks to beat impressive Empoli 2-1.
Napoli welcome Sampdoria to San Paolo, looking to bounce back after defeat to Sassuolo in Week 1.
Both Roma and Juventus will be attempting to bag their first three points of the season following mediocre results on matchday one.
Fiorentina and Torino face off at Stadio Olimpico on Sunday hoping to make it two wins in two.
This second round encounter pits two teams in Udinese and Palermo who both enjoyed a season-opening win last weekend against each other.