Carpi made a stunning debut under new Coach Beppe Sannino, beating third-placed Torino 2-1 for their historic first Serie A victory.
Chievo fought back to deny Hellas their first victory of the season in a battling Derby di Verona.
A late Massimo Maccarone header gave Empoli victory and ended Sassuolo’s unbeaten record.
Fiorentina became the sole Serie A leaders with a comfortable victory over 10-man Atalanta.
Juventus fought back from an early scare to beat Bologna 3-1 with Sami Khedira scoring on his Serie A debut.
Lazio struggled and were saved by the woodwork, but eventually saw off Frosinone 2-0 in the local derby.
Lorenzo Insigne scored two goals and set up another for Allan as Napoli sent a message by destroying Milan 4-0 at San Siro.
Gervinho bagged a brace as Roma staved off a late Palermo push to get all three points in Sicily.
Inter fought back from Luis Muriel’s opener to snatch a point at Sampdoria with Ivan Perisic, but Joaquin Correa’s miss was astonishing.
Antonio Di Natale’s goal was cancelled out by Diego Perotti as Udinese and Genoa shared the spoils.