Napoli host Club Brugge in their opening Europa League fixture with Jose Callejon, Gonzalo Higuain and Dries Mertens.
It kicks off at 18.00 UK time (17.00 GMT), follow all the action as it happens on our LIVEBLOG.
The pressure is already mounting on Coach Maurizio Sarri, who has scraped two points from the first three Serie A games.
Napoli host Club Brugge in their opening Europa League fixture with Jose Callejon, Gonzalo Higuain and Dries Mertens.
It kicks off at 18.00 UK time (17.00 GMT), follow all the action as it happens on our LIVEBLOG.
The pressure is already mounting on Coach Maurizio Sarri, who has scraped two points from the first three Serie A games.
This will be his first ever foray into European football and he returns to a 4-3-3 system, picking Callejon, Higuain and Mertens.
Marek Hamsik also keeps his spot in midfield, but Jorginho steps in for the not 100 per cent fit Mirko Valdifiori.
There’s a revolution in defence, an area of the side that has been consistently problematic in recent years for Napoli, though Raul Albiol starts again.
Club Brugge have their own issues to deal with, as absentees include Bjorn Engels, Felipe Gedoz and Jean-Charles Castelletto.
They qualified directly into the Europa League after winning the Belgian Cup.
Elsewhere in Group D, Midtjylland take on Legia Warsaw.
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Hamsik, Jorginho, David Lopez; Callejon, Higuain, Mertens
Napoli bench: Gabriel, Maggio, Chiriches, Allan, Valdifiori, Gabbiadini, Insigne
Club Brugge: Bolat; Meunier, Duarte, Mechele, De Bock; Vormer, Simons, Vazquez; Leandro Pereira, Diaby, Bolingoli
Club Brugge bench: Bruzzese, De Fauw, Cools, Claudemir, Vanaken, Vossen, Izquierdo