Sassuolo aim to build on their shock victory at San Siro by hosting an Udinese side without Antonio Di Natale.
It kicks off at the Mapei Stadium in Reggio Emilia at 17.00 GMT, click here for a match preview.
The Neroverdi are fresh from an historic 2-1 win over Milan at the Stadio Meazza on Tuesday, where they fought back from an early goal to get the result.
Sassuolo aim to build on their shock victory at San Siro by hosting an Udinese side without Antonio Di Natale.
It kicks off at the Mapei Stadium in Reggio Emilia at 17.00 GMT, click here for a match preview.
The Neroverdi are fresh from an historic 2-1 win over Milan at the Stadio Meazza on Tuesday, where they fought back from an early goal to get the result.
Domenico Berardi is again pulling the strings with Simone Zaza and Antonio Floro Flores ready to finish off the moves in a 4-3-3 attack, dropping San Siro goalscorer Nicola Sansone.
Defender Sime Vrsaljko starts on his 23rd birthday.
Gianluca Pegolo, Thomas Manfredini and Federico Peluso are sidelined with Saphir Taider on African Cup of Nations duty.
Udinese are usually reliant on star striker Di Natale, but he was forced to leave the training camp earlier today when coming down with flu symptoms.
Orestis Karnezis has also been suffering from flu, but the goalkeeper is passed fit to start.
Also absent are Giovanni Pasquale and Giampiero Pinzi, while Emmanuel Badu, Wague and Lucas Evangelista are on international duty.
It means Spanish forward Alexander Geijo has to lead the line with Cyril Thereau and Gabriel Silva.
Sassuolo: Consigli; Vrsaljko, Acerbi, Cannavaro, Longhi; Magnanelli, Missiroli, Brighi; Berardi, Floro Flores, Zaza
Sassuolo bench: Pomini, Polito; Antei, Bianco, Ariaudo, Terranova, Gazzola, Biondini, Chibsah, Pavoletti, Sansone, Floccari
Udinese: Karnezis; Danilo, Domizzi, Piris, Widmer; Gabriel Silva, Allan, Guilherme; Kone; Thereau, Geijo
Udinese bench: Scuffet, Meret; Bubnjic, Heurtaux, Fernandes, Jankto, Jaadi, Hallberg