Inter badly need a boost after recent setbacks and welcome Bologna with Ricky Alvarez and Hernanes starting.
It kicks off at San Siro at 19.45 UK time (18.45 GMT), click here for a match preview.
Walter Mazzarri is under increasing pressure after picking up just two points from the last three rounds, having thrown away a 2-0 lead at Livorno.
There is a particular desire to get the three points tonight, as Bologna won here 1-0 last season to cause a huge upset.
Andrea Ranocchia and Yuto Nagatomo return to the starting XI with Danilo D’Ambrosio filling in for the injured Jonathan on the right.
The big changes are in midfield, where Alvarez, Esteban Cambiasso and Hernanes start together, supporting Rodrigo Palacio and Mauro Icardi.
It means that once again Croatian prodigy Mateo Kovacic is left on the bench.
Bologna have lost three of their last four games and hanging on the edge of the relegation zone.
Jonathan Cristaldo steps in for Rolando Bianchi to lead the attack with Panagiotis Kone making a crucial comeback from injury to bring much-needed creativity.
It’s a special game for Rene Krhin, who grew up in the Inter youth academy.
Inter: Handanovic; Rolando, Ranocchia, Juan Jesus; D'Ambrosio, Hernanes, Cambiasso, Alvarez, Nagatomo; Icardi, Palacio
Bologna: Curci; Antonsson, Natali, Mantovani; Garics, Pazienza, Krhin, Christodoulopoulos, Cech; Kone; Cristaldo
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!