Clarence Seedorf makes his Milan debut with Keisuke Honda, Mario Balotelli, Kaka and Robinho against Verona.
It kicks off at 19.45 GMT, click here for a match preview.
Seedorf was still a player at Botafogo until the middle of this week, when he terminated his contract early to replace Massimiliano Allegri.
He knows the club well, having spent 10 years at San Siro, but begins a new stage of his career as a tactician.
The Dutchman immediately transforms Allegri’s approach, opting for a 4-2-3-1 system that has Honda, Kaka and Robinho supporting Balotelli.
Giampaolo Pazzini, Stephan El Shaarawy, Ignazio Abate, Marco Amelia, Kevin Constant, Riccardo Saponara and the suspended Sulley Muntari are unavailable.
Verona beat Milan 2-1 in the opening weekend and are still in a very prestigious sixth place with 10 more points under their belts than the Rossoneri.
Recently their form has begun to slide, as they were beaten 3-0 by Napoli last week and sold star midfielder Jorginho to the Partenopei.
Veteran centre-forward Luca Toni has missed this trip with flu symptoms, so Daniele Cacia has to take over with talented Argentine Juan Manuel Iturbe.
Hellas have never won at San Siro with nine draws and 14 defeats here.
Milan: 32 Abbiati; 2 De Sciglio, 17 Zapata, 25 Bonera, 28 Emanuelson; 18 Montolivo, 34 De Jong; 10 Honda, 22 Kakà, 7 Robinho; 45 Balotelli
Milan bench: 35 Coppola, 59 Gabriel, 5 Mexes, 13 Rami, 14 Birsa, 16 Poli, 23 Nocerino, 24 Cristante, 26 Silvestre, 37 Petagna, 81 Zaccardo
Verona: 1 Rafael; 23 Gonzalez, 18 Moras, 22 Maietta, 33 Agostini; 2 Romulo, 14 Cirigliano, 10 Hallfredsson; 15 Iturbe, 8 Cacia, 21 Gomez Taleb
Verona bench: 12 Nicolas, 98 Borra, 3 Albertazzi, 5 Donati, 6 Martinho, 11 Jankovic, 16 Rubin, 17 Donsah, 25 Marques, 29 Cacciatore, 30 Donadel
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!