Alessandro Matri, Mario Balotelli and Kaka start as Milan try to end their negative streak against on form Genoa.
It kicks off at San Siro at 19.45 GMT, click here for a match preview.
Massimiliano Allegri remains under pressure after scraping just two points from the last four Serie A rounds.
Genoa, on the other hand, have been transformed since Gian Piero Gasperini replaced Fabio Liverani, notching up three consecutive victories.
The Rossoneri must rely on history for reassurance, as Genoa haven’t conquered San Siro since 1958, going 22 Serie A visits without a victory.
Riccardo Montolivo is suspended, joining the injured Marco Amelia, Stephan El Shaarawy, Mattia De Sciglio, Giampaolo Pazzini, Antonio Nocerino and Cristian Zaccardo.
Balotelli is therefore joined by misfiring Matri and veteran Kaka, while Andrea Poli steps into the midfield.
Kevin Constant is again dropped in favour of Urby Emanuelson at left-back. Philippe Mexes pulled out in the warm-up, so Daniele Bonera gets his first start of the season.
Genoa must do without Juraj Kucka in midfield, but ex-Milan man Luca Antonini faces his former teammates for the first time since his departure over the summer.
Alberto Gilardino is another ex-Rossoneri man and leads the trident attack.
Milan: Abbiati; Abate, Zapata, Bonera, Emanuelson; Poli, De Jong, Muntari; Kaka; Matri, Balotelli
Milan bench: Gabriel, Coppola, Bonera, Silvestre, Constant, Cristante, Saponara, Birsa, Niang, Robinho
Genoa: Perin; Antonini, Portanova, Manfredini; Vrsaljko, Biondini, Matuzalem, Sampirisi; Fetfatzidis, Gilardino, Antonelli
Genoa bench: Bizzarri, De Maio, Gamberini, Bertolacci, Marchese, Lodi, Cofie, Centurion, Stoian, Calaiò, Santana, Konate
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!