Napoli’s enthusiasm is sky high and they host a Catania side in crisis under new Coach Gigi De Canio.
It kicks off at the Stadio San Paolo at 19.45 GMT, click here for a match preview.
Rafa Benitez’s men are feeling confident after the midweek 2-1 victory away to Fiorentina, albeit with a controversial finale.
Christian Maggio saw red in that game and is therefore suspended, joining the injured Juan Camilo Zuniga and Miguel Angel Britos in the stands.
Lorenzo Insigne, Marek Hamsik and Jose Maria Callejon support Gonzalo Higuain.
Catania are in crisis, as sacking Rolando Maran to bring in Gigi De Canio has not improved their fortunes.
In fact, the 4-0 midweek defeat to Juventus added insult to injury with Gonzalo Bergessio ruled out for at least two months with a fractured fibula.
Tiberio Guarente is suspended with Nicolas Spolli, Giuseppe Bellusci, Pablo Barrientos and Jaroslav Plasil sidelined.
Maxi Lopez is given a rare start, while Nicola Legrottaglie is back in defence.
Catania’s only ever Serie A victory at the San Paolo was 1-0 in 1960-61.
Napoli: Reina; Mesto, Fernandez, Albiol, Armero; Dzemaili, Behrami; Insigne, Hamsik, Callejón; Higuain
Napoli bench: Rafael, Colombo, Cannavaro, Uvini, Radosevic, Inler, Bariti, Pandev, Mertens, Zapata
Catania: Andujar; Alvarez, Gyomber, Legrottaglie, Capuano; Izco, Tachtsidis, Almiron, Castro, Biraghi; Maxi Lopez
Catania bench: Frison, Ficara, Rolin, Freire, Leto, Keko, Petkovic
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.