Vladimir Petkovic is under increasing pressure on the Lazio bench as he welcomes a fired up Cagliari.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
Lazio are struggling badly of late, losing to Atalanta last week and held 0-0 by Apollon Limassol in Cyprus on Thursday.
The injury list is extensive with Giuseppe Biava, Abdoulay Konko, Senad Lulic and the suspended Stefano Mauri.
Miroslav Klose and Cristian Ledesma are not 100 per cent fit either, while Hernanes is rested, so 20-year-old South American talents Brayan Perea and Felipe Anderson start.
Federico Marchetti faces his former club, who forced him to sit in the stands for a year in a contract dispute. Bruno Pereirinha is a surprise starter.
Cagliari are feeling confident after finally returning to their home stadium last week, their first game at the Stadio Sant’Elia since April 2012.
That ended in a victory over Catania with Victor Ibarbo and Mauricio Pinilla on target, but the Chilean is benched in favour of Marco Sau.
Albin Ekdal is still unavailable in midfield, though Daniele Conti, Daniele Dessena and Radja Nainggolan line up.
Cagliari won two in a row here, 4-1 in January 2009 and 1-0 in October 2009. However, that was followed by three consecutive defeats.
It’s traditionally a fiery affair with eight red cards and 43 yellows in the last 16 meetings between these teams, home and away.
Lazio: Marchetti; Pereirinha, Cana, Novaretti, Radu; Onazi, Biglia, Felipe Anderson; Candreva, Perea, Ederson
Cagliari: Agazzi; Perico, Rossettini, Astori, Murru; Dessena, Conti, Nainggolan; Cabrera; Ibarbo, Sau
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.