Sampdoria hope to finally kick-start their season, but host an Atalanta side with three consecutive victories.
It kicks off at 17.00 UK time (16.00 GMT) at Marassi, click here for a match preview.
Delio Rossi’s side finally notched up their first win of the campaign last week, surprising Livorno in stoppages, but remain in the danger zone with just six points from eight games.
Sansone and Bartosz Salamon are sidelined for the hosts, while Manolo Gabbiadini faces his former club, as he grew up in the Atalanta youth academy.
Atalanta are coming off three consecutive victories and hope to add a fourth at Marassi.
However, Coach Stefano Colantuono has to do without the injured Giacomo Bonaventura, Luigi Giorgi, Giulio Migliaccio and Stefano Lucchini.
Franco Brienza and veteran Mario Yepes therefore step into the starting XI, as Maxi Moralez continues to support hitman German Denis.
Sampdoria: Da Costa; Mustafi, Gastaldello, Costa; De Silvestri, Palombo, Obiang, Regini; Bjarnason; Gabbiadini, Eder
Sampdoria bench: Fiorillo, Garcia, Rodriguez, Castellini, Pozzi, Wszolek, Barillà, Soriano, Gentsoglou, Poulsen, Petagna, Fornasier
Atalanta: Consigli; Bellini, Stendardo, Yepes, Del Grosso; Raimondi, Cigarini, Carmona, Brienza; Moralez; Denis
Atalanta bench: Sportiello, Scaloni, Livaja, Canini, Baselli, Brivio, Cazzola, Gagliardini, Marilungo, Kone, De Luca, Nica
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!