Bad news for Juventus, as Martin Caceres has a suspected torn meniscus while on international duty.
The Uruguay medical staff released a statement confirming he will not take part in the game against Colombia due to this knee injury.
Defender Caceres sustained the setback during a World Cup qualifier with Peru earlier this week.
He will now fly back to Italy in order to undergo further tests and decide on a course of action.
Check out OLBG.com's list of ££ Free Bets from UK bookmakers before placing your bets!