Walter Mazzarri makes his Serie A bow on the Inter bench, welcoming Fabio Liverani’s Genoa to San Siro.
It kicks off at 17.00 UK time (16.00 GMT) at the Stadio Giuseppe Meazza in Milan. Click here for a match preview.
Mazzarri has transformed the Nerazzurri’s tactics over the summer, bringing in his trademark three-man defence.
Cristian Chivu, Walter Samuel, Javier Zanetti and Diego Milito are out injured, while Ezequiel Schelotto is not part of the Coach’s plans.
Saphir Taider is on the bench just days after arriving from Bologna, while Ricky Alvarez backs up Rodrigo Palacio.
Mateo Kovacic is still not 100 per cent fit, so Zdravko Kuzmanovic starts instead.
Genoa have a Serie A debutant boss, as Liverani only retired from football in 2011 and so far his management experience has been the Genoa Primavera youth team.
Their season got off to the worst possible start with Coppa Italia exit on penalties to Spezia.
Francelino Matuzalem is a last-minute addition to the squad, but Davide Biondini and Giovanni Marchese sit out bans.
Alberto Gilardino leads the attack with support from Francesco Lodi, Andrea Bertolacci and Mario Alberto Santana.
Inter: Handanovic; Campagnaro, Ranocchia, Juan Jesus; Jonathan, Guarin, Cambiasso, Kuzmanovic, Nagatomo; Alvarez; Palacio
Genoa: Perin; Vrsaljko, Manfredini, Portanova, Antonelli; Kucka, Lodi, Cofie; Bertolacci, Santana; Gilardino
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.