Lazio host Delio Rossi’s Sampdoria and hope to add a third consecutive victory so they can secure a place in Europe.
It kicks off at the Olimpico at 14.00 UK time (13.00 GMT), click here for a match preview.
The Aquile have rediscovered their form with two wins on the bounce, including a 6-0 demolition job on Bologna.
Ederson, Michael Ciani, Stefano Mauri and Abdoullay Konko are on the treatment table, while Cristian Brocchi announced his retirement due to injury.
Miroslav Klose leads the attack with support from Sergio Floccari and Hernanes.
Sampdoria are mathematically safe from the threat of relegation, even though they are without a win in nine rounds.
Nenad Krsticic and Andrea Costa are unavailable, but Enzo Maresca gets a rare start.
Lazio: Marchetti; Gonzalez, Biava, Cana, Radu; Candreva, Onazi, Hernanes, Lulic; Floccari, Klose
Lazio bench: Bizzarri, Guerrieri, Stankevicius, Dias, Crecco, Ledesma, Kozak, Rozzi, Saha
Sampdoria: Da Costa, Gastaldello, Mustafi, Rossini; Rodriguez, Poli, Munari, Maresca, Poulsen; Sansone, Icardi
Sampdoria bench: Romero, Berni, Palombo, Castellini, De Silvestri, Obiang, Renan, Maxi Lopez, Berardi, Estigarribia, Soriano, Eder
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!