There are weather warnings in place in Genoa for Sunday evening, so Sampdoria-Inter could be at risk.
The Serie A match is set to kick off at 19.45 GMT at the Stadio Luigi Ferraris, commonly known as Marassi.
Weather warnings are in place for Genoa, as heavy rain, sub-zero temperatures and possibly also snow are expected from 17.00 GMT on Sunday.
A final decision is due to be made tomorrow morning, as local authorities want to avoid thousands of people flocking to the stadium in dangerous conditions.
The city of Genoa has suffered from flash floods in recent years, leading to several casualties.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!