Milan assistant manager Mauro Tassotti feels Lazio need to be respected, though Stephan El Shaarawy has recovered to start.
“Lazio are a strong side with important qualities. We are fairly confident, because the team is doing well, but it is going to be a difficult and complicated match,” he told Milan Channel.
Kick-off at San Siro is at 19.45 GMT and only two points separate them in the battle for third place.
“If they have two more points in the table than we do, then it means Lazio are a good side. They defend well, so we must play with legs and head. It won’t be easy.”
Mario Balotelli is ruled out with a bruised shin, but El Shaarawy is able to start despite suffering from flu symptoms recently.
“Stephan is fine, he trained regularly and overcame the slight bout of flu.”
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.