Juventus welcome arch-rivals Fiorentina in a fiery clash, as Claudio Marchisio returns to face Stevan Jovetic and Luca Toni.
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These clubs have long had a fierce rivalry which escalated again before the game with a video posted on the official Juve website.
Leonardo Bonucci lost his appeal against a two-match ban for insulting the referee, while Giorgio Chiellini, Simone Pepe, Mauricio Isla and Nicklas Bendtner are injured.
Mirko Vucinic returns from suspension and partners Alessandro Matri, but Coach Antonio Conte is again in the stands with a touchline ban.
Marchisio returns from his injury to bolster the midfield and make his 200th official appearance for Juventus, while Luca Marrone and Federico Peluso join Andrea Barzagli in defence.
Fiorentina had a disastrous start to 2013, but finally registered their first win of the calendar year last week against Parma.
Alberto Aquilani and Giulio Migliaccio are suspended, joining the injured Giuseppe Rossi and Mati Fernandez.
Toni takes on his former club along with Jovetic, while Juan Cuadrado and Romulo complete the midfield.
Juventus: Buffon; Peluso, Marrone, Barzagli; De Ceglie, Marchisio, Pirlo, Vidal, Lichtsteiner; Vucinic, Matri
Juventus bench:Storari, Rubinho, Caceres, Pogba, Giovinco, Anelka, Padoin, Giaccherini, Quagliarella
Fiorentina: Viviano; Roncaglia, Rodriguez, Savic; Cuadrado, Romulo, Pizarro, Borja Valero, Pasqual; Jovetic, Toni
Fiorentina bench: Neto, Lupatelli, Tomovic, Compper, Bernardeschi, Wolski, Capezzi, Llama, Ljajic, Larrondo, El Hamdaoui
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