Inter visit Udinese in the lunchtime kick-off, while Juventus welcome Sampdoria and this evening there’s a scorching Napoli-Roma.
Milan take on Beppe Iachini’s Siena and there are relegation dogfights in Verona, Genoa and Parma.
Click here for all the individual match previews, plus reports from Saturday’s games Catania-Torino and Lazio-Cagliari.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!