Fiorentina crushed Palermo 3-0 and Lazio ruined Sampdoria boss Delio Rossi’s debut to go into second place, while Parma also earned a big away win at Bologna in the Emilia-Romagna Derby.
Elsewhere Udinese held Atalanta, Torino pushed past Chievo and Napoli surprised Siena.
On Friday Juventus fought back to beat Cagliari on neutral turf and Pescara earned a last- minute victory over Catania.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.