Paul Pogba, Fabio Quagliarella, Mauricio Isla and Lucio get the chance to start as Juventus welcome Chievo this evening.
The Bianconeri make several changes to their squad in Turin between big games against Chelsea and Fiorentina.
It kicks off at the Juventus Stadium at 19.45 UK time, 20.45 local, and you can watch it LIVE on your PC.
Coach Antonio Conte and assistant Massimo Carrera are forced to rotate the squad after their Champions League opener at Stamford Bridge, particularly for the fatigued Andrea Pirlo.
He is rested in favour of former Manchester United midfielder Pogba, while Isla, Lucio and Giaccherini are also introduced.
Quagliarella’s wonderful goal against Chelsea earns him a starting spot in place of Sebastian Giovinco to partner Mirko Vucinic.
Andrea Barzagli, Arturo Vidal, Stephan Lichtsteiner, Pirlo and Giovinco are all rested. Simone Pepe and Simone Padoin are sidelined.
Chievo have a surprisingly good history with Juve, as they have drawn four of their last five encounters, home and away.
Luciano suffered a thigh problem this week and joins Boukary Drame, Alberto Paloschi and Lorenzo Squizzi on the treatment table.
As always, Sergio Pellissier leads the attack, but this time he has support from ex-Juventus youth product Marco Rigoni.
Juventus: Buffon; Lucio, Bonucci, Chiellini; Isla, Giaccherini, Pogba, Marchisio, Asamoah; Vucinic, Quagliarella
Chievo: Sorrentino; Frey, Dainelli, Cesar, Jokic; Vacek, L Rigoni, Hetemaj; Thereau, M Rigoni; S Pellissier
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.